Actos is ‘alternative’ to banned diabetes drug Avandia

A drug to treat diabetes, Actos, would be a “sensible alternative” to one which was banned last year, researchers have said.

Avandia, also known as rosiglitazone, was suspended by authorities in Europe, but is still available in the United States and Canada.

The study published on the BMJ website said patients taking Actos had fewer heart problems.

Diabetes UK said Actos was a very effective treatment.

Rosiglitazone and pioglitazone, which has the trade name Actos, are used to control blood sugar levels in patients with type-2 diabetes and both are known to increase the risk of heart failure.

The research team at the University of East Anglia compared the risks associated with each drug by analysing 16 studies of more 800,000 patients.

Rosiglitazone increased the risk of heart attack by 16%, heart failure by 23%, and death by 14% compared with pioglitazone.


The report says: “For patients who need thiazolidinedione treatment, continued use of rosiglitazone may lead to excess heart attacks, heart failure and mortality, compared with pioglitazone, the effect on public health may be considerable.”

Dr Yoon Loke, from the Univeristy of East Anglia, told the BBC: “For patients who have come off rosiglitazone, pioglitazone would be a sensible alternative.”

“Although it’s like jumping out of the frying pan and into the fire in some ways, pioglitazone can lead to fractures in women, is being evaluated for risk in bladder cancer and increases the risk of heart failure.”

Deepa Khatri, clinical advisor at Diabetes UK, said people with diabetes should have as much choice as possible.

“Actos (pioglitazone) is still available on the European market for people with diabetes.

“For many people, Actos is a very effective treatment to help control blood glucose levels and Diabetes UK believes this drug should continue to be made available to ensure people with diabetes have as much choice as possible.

“Alternatives to Actos are available, however is it very important that people discuss treatment options with their healthcare team to assess the most appropriate form of medication to suit their individual needs.”

Leave a Reply

Protected by WP Anti Spam

International News

Sultan: let’s live in peace as one
Sultan: let’s live in peace as one

FacebookTwitterGoogle+PinterestLinkedInWhatsApp The Sultan of Sokoto and President -General, Nigerian Supreme Council for Islamic Affairsý(NSCIA), Muhammad Sa’ad Abubakar III, has appealed to Nigerians to live in peace with one another for the unity

Read more

Is It True That A Senator Gets N3b Yearly, SERAP Asks Saraki
Is It True That A Senator Gets N3b Yearly, SERAP Asks Saraki

Bukola Saraki, Senate President Socio-Economic Rights and Accountability Project (SERAP) has urged the Senate President Dr Bukola Sakari to “urgently explain to Nigerians if it is true that a Nigerian Senator

Read more

The people’s constitution Nigeria needs, by Afe Babalola, other Yoruba leaders
The people’s constitution Nigeria needs, by Afe Babalola, other Yoruba leaders

The large crowd that attended last Thursday’s Yoruba Summit on restructuring was large. Those in attendance cut across religious, political and ethnic boundaries. From left: Governor Ayo Fayose of Ekiti State,

Read more


Photo Gallery

Log in | Designed by Platinum Consolidated| Hostgator Coupons
Get Adobe Flash player